AS/NZS 4308:2001

1 - AS/NZS 4308:2001 PROCEDURES FOR THE COLLECTION, DETECTION AND QUANTITATION OF DRUGS OF ABUSE IN URINE
4 - PREFACE
5 - CONTENTS
7 - SECTION 1 SCOPE AND GENERAL
7 - 1.1 SCOPE
7 - 1.2 REFERENCED DOCUMENTS
8 - 1.3 DEFINITIONS
8 - 1.3.1 Benzodiazepines
8 - 1.3.2 Calibration standard
8 - 1.3.3 Cannabis metabolite
8 - 1.3.4 Chain-of-custody
8 - 1.3.5 Chain-of-custody form
8 - 1.3.6 Cocaine metabolites
8 - 1.3.7 Collection site
8 - 1.3.8 Collector
8 - 1.3.9 Confirmatory test
8 - 1.3.10 Control sample
8 - 1.3.11 Cut-off level
8 - 1.3.12 Drug-free
8 - 1.3.13 Initial test
9 - 1.3.14 Laboratory
9 - 1.3.15 Laboratory sample
9 - 1.3.16 Opiates
9 - 1.3.17 Permanent record system
9 - 1.3.18 Proficiency testing program
9 - 1.3.19 Referee sample
9 - 1.3.20 Reference compound
9 - 1.3.21 Sympathomimetic amines
9 - 1.3.22 Test portion
9 - 1.4 PRINCIPLE
9 - 1.5 REAGENTS
10 - 1.6 APPARATUS
10 - 1.6.1 Volumetric glassware
10 - 1.6.2 Piston operated volumetric apparatus
10 - 1.6.3 Thermometer
10 - 1.6.4 Clinical chemistry analyser
10 - 1.6.5 Gas chromatograph
10 - 1.6.6 Gas chromatograph/mass spectrometer
10 - 1.6.7 High pressure liquid chromatograph
10 - 1.6.8 Liquid chromatograph/mass spectrometer
11 - SECTION 2 PERSONNEL
11 - 2.1 DAY-TO-DAY MANAGEMENT
11 - 2.2 TEST VALIDATION
11 - 2.3 OPERATION AND SUPERVISION OF ANALYSTS
12 - SECTION 3 SPECIMEN COLLECTION AND STORAGE PROCEDURES
12 - 3.1 GENERAL
12 - 3.2 COLLECTION SITE
12 - 3.2.1 General
12 - 3.2.2 Privacy
12 - 3.2.3 Security
12 - 3.2.4 Chain-of-custody
12 - 3.2.5 Access
12 - 3.3 INTEGRITY AND IDENTITY OF THE COLLECTED SPECIMEN
12 - 3.3.1 General
13 - 3.3.2 Precautions
13 - 3.3.3 Collection procedure
14 - 3.3.4 Preparation for dispatch
14 - 3.4 TRANSPORTATION TO THE LABORATORY
14 - 3.5 SPECIMEN RECEPTION
15 - 3.6 LABORATORY SECURITY
15 - 3.7 STORAGE OF LABORATORY SAMPLES
15 - 3.7.1 Short-term refrigerated storage
15 - 3.7.2 Long-term refrigerated storage
16 - SECTION 4 INITIAL TESTING
16 - 4.1 GENERAL
16 - 4.2 METHOD
16 - 4.3 NUMBER OF DETERMINATIONS
17 - 4.4 BLANK DETERMINATION
17 - 4.5 QUALITY CONTROL
17 - 4.6 INITIAL TEST CUT-OFF LEVELS
17 - 4.7 ACCEPTANCE OF RESULTS
17 - 4.8 INTERPRETATION OF RESULTS
19 - SECTION 5 CONFIRMATORY TESTING PROCEDURES
19 - 5.1 CONFIRMATION OF INITIAL TESTING
19 - 5.2 INSTRUMENT CONDITIONS
19 - 5.3 NUMBER OF DETERMINATIONS
19 - 5.4 BLANK DETERMINATION
19 - 5.5 INSTRUMENT SETUP
19 - 5.6 QUALITY CONTROL
20 - 5.7 CONFIRMATORY TEST CUT-OFF LEVELS
20 - 5.8 CALCULATIONS
20 - 5.9 ACCEPTANCE OF RESULTS
22 - SECTION 6 REPORTING OF RESULTS
22 - 6.1 TEST REPORT
22 - 6.2 RECORD KEEPING
22 - 6.3 DISPUTED RESULTS
23 - APPENDIX A - EXAMPLE OF CHAIN-OF-CUSTODY FORM
25 - APPENDIX B - RECOMMENDED PRECAUTIONS FOR HANDLING BIOLOGICAL SPECIMENS
25 - B1 GENERAL RECOMMENDATIONS
25 - B2 DISINFECTION OF SPILLS
26 - B3 DISINFECTION OF EQUIPMENT
26 - B4 WASTE DISPOSAL
26 - B5 BIBLIOGRAPHY
27 - APPENDIX C - PRINCIPLES OF OPERATION
27 - C1 GAS CHROMATOGRAPHY
27 - C2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
27 - C3 HIGH PRESSURE LIQUID CHROMATOGRAPHY
27 - C4 IMMUNOASSAY
28 - C5 LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY