Name: ASTM E 1262 : 1988 : R1996
Brand: ASTM
Price: 122.77 AUD

ASTM E 1262 : 1988 : R1996

Superseded

Standard Guide for Performance of the Chinese Hamster Ovary Cell/Hypoxanthine Guanine Phosphoribosyl Transferase Gene Mutation Assay

Available format(s)

Hardcopy , PDF

Superseded date

11-11-2014

Language(s)

English

Published date

01-01-1996

Publisher

American Society for Testing and Materials

CONTAINED IN VOL. 13.01, 2018 Describes the more relevant biological concepts as they are currently understood, and summarizes the critical technical aspects for acceptable bioassay performances as they currently are perceived and practiced.

1.1 This guide highlights some of the more relevant biological concepts as they are currently understood, and summarizes the critical technical aspects for acceptable bioassay performances as they currently are perceived and practiced. The Chinese hamster ovary cell/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay (1) has been widely applied to the toxicological evaluation of industrial and environmental chemicals.

1.2 This guide concentrates on the practical aspects of cell culture, mutagenesis procedures, data analysis, quality control, and testing strategy. The suggested approach represents a consensus of the panel members for the performance of the assay. It is to be understood, however, that these are merely general guidelines and are not to be followed without the use of sound scientific judgement. Users of the assay should evaluate their approach based on the properties of the substances to be tested and the questions to be answered.

1.3 Deviation from the guidelines based on sound scientific judgement should by no means invalidate the results obtained.

1.4 This standard may involve hazardous materials, operations, and equipment. This standard does not purport to address all of the safety problems associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

Committee	F 04
DocumentType	Guide
Pages	5
ProductNote	Reconfirmed 1996
PublisherName	American Society for Testing and Materials
Status	Superseded
SupersededBy	ASTM E 1262 : 1988 : R2003

ASTM F 1439 : 2003 : R2018	Standard Guide for Performance of Lifetime Bioassay for the Tumorigenic Potential of Implant Materials
ASTM F 748 : 2016	Standard Practice for Selecting Generic Biological Test Methods for Materials and Devices