• There are no items in your cart
We noticed you’re not on the correct regional site. Switch to our AMERICAS site for the best experience.
Dismiss alert

ASTM E 1280 : 1997

Withdrawn
Withdrawn

A Withdrawn Standard is one, which is removed from sale, and its unique number can no longer be used. The Standard can be withdrawn and not replaced, or it can be withdrawn and replaced by a Standard with a different number.

View Superseded by
withdrawn

A Withdrawn Standard is one, which is removed from sale, and its unique number can no longer be used. The Standard can be withdrawn and not replaced, or it can be withdrawn and replaced by a Standard with a different number.

Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity
Available format(s)

Hardcopy , PDF

Withdrawn date

30-11-2014

Language(s)

English

Published date

01-01-1997

CONTAINED IN VOL. 11.05, 2012 Gives background material and criteria for conducting of the L5178Y/TK[+/-] -3.7.2C mouse lymphoma mutagenicity assay (known as the mouse lymphoma assay) (MLA) in order that the protocols and procedures are properly understood and evaluated.

1.1 The purpose and scope of this guide is to present background material and to establish criteria by which protocols and procedures for conducting the L5178Y/TK +/- 3.7.2C mouse lymphoma mutagenicity assay (commonly referred to as the mouse lymphoma assay, (MLA)) can be properly understood and evaluated. These guidelines are also intended to aid researchers and others to gain a better understanding of the critical elements involved with mammalian cell mutagenicity testing. More specifically, this guide is intended to provide for researchers the accomplishment of the following goals:

1.1.1 Provide an understanding of the critical procedures (steps) in the performance of this mammalian cell mutagenicity test.

1.1.2 Provide generalized criteria by which researchers can evaluate if they are properly performing, utilizing, and interpreting this assay.

1.1.3 Provide criteria by which individuals responsible for evaluating MLA data can determine if the experiments have been properly performed and interpreted.

1.1.4 Provide a basis from which new procedures and developments in testing procedures can be evaluated.

1.1.5 Provide an understanding of the types of genetic damage (that is, gene and chromosomal mutation) that may be detected in this mammalian cell mutagenicity test.

Committee
F 04
DocumentType
Guide
Pages
9
ProductNote
Reconfirmed 1997
PublisherName
American Society for Testing and Materials
Status
Withdrawn
SupersededBy

ASTM F 1439 : 2003 : R2018 Standard Guide for Performance of Lifetime Bioassay for the Tumorigenic Potential of Implant Materials

View more information
£62.61
Excluding VAT

Access your standards online with a subscription

Features

  • Simple online access to standards, technical information and regulations.

  • Critical updates of standards and customisable alerts and notifications.

  • Multi-user online standards collection: secure, flexible and cost effective.