This part of ISO 6145 specifies a dynamic method using permeation membranes for the preparation of calibrationgas mixtures containing component mole fractions ranging from 10−9 and 10−6. A relative expanded uncertainty of2,5 % of the component mole fraction can be achieved using this method. In the mole fraction range considered, itis difficult to maintain some gas mixtures, for example in cylinders, in a stable state. It is therefore desirable toprepare the calibration gas immediately before use, and to transfer it by the shortest possible path to the placewhere it is to be used. This technique has been successfully applied in generating low content calibration gasmixtures of, for example, sulfur dioxide (SO2), nitrogen dioxide (NO2) and benzene (C6H6) in air.If the carrier gas flow is measured as a gas mass-flow, the preparation of calibration gas mixtures using permeationtubes is a dynamic-gravimetric method which gives contents in mole fractions.