Name: ASTM E 1242 : 1997 : R2014
Brand: ASTM
Price: 66.00 USD

ASTM E 1242 : 1997 : R2014

Superseded

Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis

Available format(s)

Hardcopy , PDF

Superseded date

03-16-2023

Language(s)

English

Published date

12-04-2014

Publisher

American Society for Testing and Materials

CONTAINED IN VOL. 11.06, 2014 Defines a procedure for estimating the fathead minnow (Pimephales promelas) 96-h LC50 of nonreactive and nonelectrolytic organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship.

1.1This practice covers a procedure for estimating the fathead minnow (Pimephales promelas) 96-h LC50 of nonreactive (that is, covalently bonded without unsaturated residues) and nonelectrolytic (that is, require vigorous reagents to facilitate substitution, addition, replacement reactions and are non-ionic, non-dissociating in aqueous solutions) organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship.2

1.2This procedure is accurate for organic chemicals that are toxic due to narcosis and are non-reactive and non-electrolytic. Examples of appropriate chemicals are: alcohols, ketones, ethers, simple halogenated aliphatics, aromatics, and aliphatic substituted aromatics. It is not appropriate for chemicals whose structures include a potential toxiphore (that structural component of a chemical molecule that has been identified to show mammalian toxicity, for example CN is known to be reponsible for inactivation of enzymes, NO₂ for decoupling of oxidative phosphorylation, both leading to mammalian toxicity). Examples of inappropriate chemicals are: carbamates, organophosphates, phenols, beta-gamma unsaturated alcohols, electrophiles, and quaternary ammonium salts.

Committee	E 50
DocumentType	Standard Practice
Pages	2
ProductNote	Reconfirmed 2014
PublisherName	American Society for Testing and Materials
Status	Superseded
SupersededBy	ASTM E 1242 : 2023
Supersedes	ASTM E 1242 : 1997 : R2008

ASTM E 1023 : 1984 : R2007	Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses
ASTM E 1023 : 1984 : R2014	Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses
ASTM E 1023 : 1984 : R2002	Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses
ASTM E 1023 : 1984 : R1996	Standard Guide for Assessing the Hazard of a Material to Aquatic Organisms and Their Uses
ASTM E 943 : 2008 : R2014	Standard Terminology Relating to Biological Effects and Environmental Fate (Withdrawn 2023)
ASTM E 1147 : 1992 : R2005	Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography (Withdrawn 2013)
ASTM E 729 : 1996	Standard Guide for Conducting Acute Toxicity Tests on Test Materials with Fishes, Macroinvertebrates, and Amphibians
ASTM E 1147 : 1992 : R1997	Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography